日本东京大学与理化学研究所的研究小组最近的一项研究结果显示,B型、AB型血女性与A型、O型血女性相比不容易患贫血。
该小组通过对大约1.5万人的遗传因子进行分析而得出的这一研究成果8日被发表在了美国的科学杂志《自然遗传学》电子版上。研究显示,是否易患一些生活常见疾病与人体对药物的适应性都会因人而异,这是由于在构成人体DNA的30亿对碱基当中有1000万对可能会出现变异所引起的。
研究小组使用高性能计算机对10类病患者的遗传因子数据进行了分析,其结果证实人体的46条染色体中的基因变异除了会影响尿酸之外,还会影响到红血球、白血球、血小板等一些血液化验项目的数值。
其中,以红血球与血型之间的关系来看,B型、AB型血的女性与A型、O型血女性相比患有贫血的几率降低了21%。研究人员认为,这是由于在形成B型、AB型的遗传因子上出现基因变异会使血色素增高从而减少患贫血的几率。
原始出处及摘要：
Nature Genetics 7 February 2010 | doi:10.1038/ng.531
Genome-wide association study of hematological and biochemical traits in a Japanese population
Yoichiro Kamatani1,2, Koichi Matsuda1, Yukinori Okada3, Michiaki Kubo4, Naoya Hosono4, Yataro Daigo1,2, Yusuke Nakamura1,5 & Naoyuki Kamatani3
We report genome-wide association studies for hematological and biochemical traits from ~14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 × 10?8). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.
1 Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
2 Department of Medical Genome Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan.
3 Laboratory for Statistical Analysis, Kanagawa, Japan.
4 Laboratory for Genotyping Development, Kanagawa, Japan.
5 Center for Genomic Medicine, RIKEN, Kanagawa, Japan.
