吡格雷（商品名：波立维）与奥美拉唑（商品名：Prilosec）的药物相互作用
[2009年11月7日公布] FDA向医护人员发出警告，是关于抗凝药氯吡格雷（波立维）与用于减少胃酸的质子泵抑制剂（PPI）奥美拉唑（Prilosec/Prilosec OTC）之间相互作用的安全新信息。新数据显示：当氯吡格雷与奥美拉唑同时服用时，氯吡格雷的效果会降低。心脏病发作或中风的高危患者应用氯吡格雷预防血凝块，若同时服用奥美拉唑，药效就会大打折扣。及时Separating氯吡格雷与奥美拉唑的剂量，并不会减少两种药物的相互作用。
可能有类似效应应避免与氯吡格雷联用的其它药物包括：西咪替丁、氟康唑、酮康唑、伏立康唑、Etravirine、非尔氨酯、氟西汀、氟伏沙明和噻氯匹定。
Clopidogrel (marketed as Plavix) and Omeprazole (marketed as Prilosec) - Drug Interaction
[Posted 11/17/2009] FDA notified healthcare professionals of new safety information concerning an interaction between clopidogrel (Plavix), an anti-clotting medication, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid. New data show that when clopidogrel and omeprazole are taken together, the effectiveness of clopidogrel is reduced. Patients at risk for heart attacks or strokes who use clopidogrel to prevent blood clots will not get the full effect of this medicine if they are also taking omeprazole. Separating the dose of clopidogrel and omeprazole in time will not reduce this drug interaction.
Other drugs that are expected to have a similar effect and should be avoided in combination with clopidogrel include: cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine, and ticlopidine.
source:www.fda.gov
